I think a Tilemap is a good candidate, especially if you think your environment can be broken into discrete chunks and the layout can conform generally to a tiling. Take some time and look up some tutorials to learn how autotiling and Tilemap layers work (you might want to check out the 4.3 beta since that has revamped how Tilemap layers work)… there’s more complexity, but you’ll be able to do more, more easily, once you learn it.
To follow up, i don’t think there’s an inherent connection between tile maps and pixel art per se, they just work well together. But tile maps can work with any art style. I think you can separate it into logistics of where things are vs the style of the graphics displayed.