Tilemap Chunkloading Efficiency

Is there any reason to use multiple Tilemaps rather than just multiple layers in a single Tilemap node? I can’t seem to find any reason to do so, all I’ve found is that older versions didn’t have multiple layers per Tilemap.

Also, I had another question, but it deviates from this topic significantly enough I made a new topic. I only mention it here as my new question somewhat stems from the same topic as this. Link is here if you’d like to view it - Setting Tiles During Runtime